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KMID : 1149220010090010273
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Korean Journal of Oriental Medical Prescription
2001 Volume.9 No. 1 p.273 ~ p.288
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The Histologic Effects of Jungcheonhwadamgangki-tang Extract on the Experimental Asthma induced by ovalbumin
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Lee Sang-Jun
Park Ji-Hyeon
Choi Hae-Yun
Kim Jong-Dae
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Abstract
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Objectives : In order to study the effect of oral administration of Jungcheonhwadamgangki-tang against the asthma.
Method : Asthma was induced to Balb/c mouse with ovalbumin by using method of Hatfield et al. It was observed the changes numbers and morphology of the mast cells in the trachea, numbers of mucous secretory cell in the bronchus, morphology of the bronchus, ultramicroscopical appearance of surface of trachea and number of cilia and mucous secretory cells by scanning electron microscope.
Result : 1. Degranulation and decreasing of the numbers of mast cells were significantly decreased in the Jungcheonhwadamgangki-tang extract group as compared with control group. 2. Hypertrophy of mucous membrane of bronchus In the lung, infiltration of inflammatory cells, increasing of mucous secretory cells in the bronchus were significantly decreased in the Jungcheonhwadamgangki-tang extract group as compared with control group. 3. Shedding, decreasing of cilia cells and increasing of mucous secretory cells in the surface of the trachea were significantly decreased in the Jungcheonhwadamgangki-tang extract group as compared with control group.
Conclusion : It is considered that Jungcheonhwadamgangki-tang has somewhat favorable effects on the asthma because the asthma specific series of abnormalities in respiratory system were decreased after oral administration of Jungcheonhwadamgangki-tang in this study. In future, it is needed that the toxicological and dosage specific study of Jungcheonwhadamgangki-tang to use against bronchial asthma with safe.
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KEYWORD
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Jungcheonhwadamgangki-tang(Dingchuanhuatanjianggi-tang) Ovalbumin, Asthma(bronchial), Electron Microscope
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